ABOUT THE BALANCE OF ELECTROLYTES IN THE BLOOD SERUM AND ITS IMPORTANCE IN THE PROGNOSTIC ASSESSMENT OF THE BODY CONDITION (EXPERIMENTAL RESEARCH)

DOI: 10.22138/2500-0918-2024-21-2-114-126

E.B. Zhakovko ¹, P.A. Torkunov ²

¹ FSBI State Research Testing Institute of Military Medicine of the Defense Ministry, Saint Petersburg, Russian Federation;

² FSBEI HPE Military Medical Academy named after S.M. Kirov, Saint Petersburg, Russian Federation

Resume. Introduction. To assess the prognostic significance of electrolyte ratios in blood serum, an experimental study was conducted that excludes the effect of infusion therapy on ion balance characteristics. Aim of the study: is to analyze the peculiarities of changes and ratios of the main blood electrolytes in the post-intoxication period of poisoning with alkylating poisons with dichlorodiethyl sulfide and carbonic acid dichlorohydride, as well as ethylene glycol. Materials and methods. In experiments of rats and mice, various models of intoxication were used, accompanied by the formation of nephropathies, pulmonary edema and resorptive lesions with alkylating substances, examples of which showed changes in the electrolyte balance. Results. It was found that with the increase in tissue alteration, a relative potassium deficiency occurs, manifested in an increase in the values of the [Na⁺]/[K⁺] and [Clˉ]/[K⁺] indices, changes in the which during poisoning with alkylating poisons coincide in time and are correlated in severity with changes in the state of the body (body weight gain, water consumption, oxygen saturation of the blood). No significant changes in serum calcium levels have been observed. Conclusion. It is shown that the indices under consideration have pathogenic significance, and their dynamics reflects peculiarities of the pathological process in poisonings. At the same time, the values and levels of proper deviations of these characteristics are not absolute, but require an individual assessment in dynamics.

Keywords: sodium; potassium; chlorine; ion balance; blood serum

There is no conflict of interest.

Contact details of the corresponding author:

Sergey V. Chepur

gniiivm_2@mil.ru

Received 02.04.2024

For citation:

Chepur S.V., Yudin M.A., Vetryakov O.V., Zhakovko E.B., Torkunov P.A. About the balance of electrolytes in the blood serum and its importance in the prognostic assessment of the body condition (experimental research). [Online] Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2024, Vol. 21, no. 2, pp. 114–126. DOI: 10.22138/2500-0918-2024-21-2-114-126 (In Russ)

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Authors

Sergey V. Chepur

State Scientific Tesr Research Institute of Military Medicine, Ministry of Defense of the Russian Federation

Doctor of Medical Science, Professor, Director